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Today’s fare is an article I was invited to submit to Forbes.com’s AI report, and was mysteriously (and very annoyingly) yanked out at the last moment. Their loss.

Enjoy.

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It will probably come as a surprise to those who are not well acquainted with the life and work of Alan Turing that in addition to his renowned pioneering work in computer science and mathematics, he also helped to lay the groundwork in the field of mathematical biology(1). turingWhy would a renowned mathematician and computer scientist find himself drawn to the biosciences?

Interestingly, it appears that Turing’s fascination with this sub-discipline of biology most probably stemmed from the same source as the one that inspired his better known research: at that time all of these fields of knowledge were in a state of flux and development, and all posed challenging fundamental questions. Furthermore, in each of the three disciplines that engaged his interest, the matters to which he applied his uniquely creative vision were directly connected to central questions underlying these disciplines, and indeed to deeper and broader philosophical questions into the nature of humanity, intelligence and the role played by evolution in shaping who we are and how we shape our world.

Central to Turing’s biological work was his interest in mechanisms that shape the development of form and pattern in autonomous biological systems, and which underlie the patterns we see in nature (2), from animal coat markings to leaf arrangement patterns on plant stems (phyllotaxis). This topic of research, which he named “morphogenesis,” (3) had not been previously studied with modeling tools. This was a knowledge gap that beckoned Turing; particularly as such methods of research came naturally to him.

In addition to the diverse reasons that attracted him to the field of pattern formation, a major ulterior motive for his research had to do with a contentious subject which, astonishingly, is still highly controversial in some countries to this day. In studying pattern formation he was seeking to help invalidate the “argument from design(4) concept, which we know today as the hypothesis of “Intelligent Design.

Turing was intent on demonstrating that the laws of physics are sufficient to explain our observations in the natural world; or in other words, that our findings do not need an omnipotent creator to explain them. It is ironic that Turing, whose work played a central role in laying the groundwork for the creation of Artificial Intelligence (AI), took a clear stance against creationism. This is testament to his acceptance of scientific evidence and rigorous research over weak analogy.

Unfortunately, those who did not and will not accept Darwinian natural selection as the mechanism of evolution will not see anything compelling in Turing’s work on morphogenesis. To those individuals, the development of AI can be taken as “proof,” or a convincing analogy, of the necessity and presence of a creator, the argument being that the Creator created humanity, and humanity creates AI.

However, what the supporters of intelligent design do not acknowledge is that natural selection is itself precisely the cause underlying the development of both humanity and its AI progeny. Just as natural selection resulted in the phenomena that Turing sought to model in his work on morphogenesis (which brings about the propagation of successful traits through the development of biological form and pattern), it is also the driver for the development of intelligence. Itself generated via internalized neuronal selection mechanisms (5, 6), intelligence allows organisms to adapt to their environment continually during life.

Intelligence is the ultimate tool, the development of which allows organisms to survive; it enables them to learn, respond to their environment and adapt their behavior within their own lifetime. It is the fruit of the natural process that brings about successive development over time in organisms faced with scarcity of resources. Moreover, it now allows humans to defy generational selection and develop intelligences external to our own, making use of computational techniques, including some which utilize evolutionary mechanisms (7).

The eventual development of true AI will be a landmark in many ways, notably in that these intelligences will have the ability to alter their own circuits (their version of neurons), immediately and at will. While the human body is capable of some degree of non-developmental neuronal plasticity, this takes place slowly and control of the process is limited to indirect mechanisms (such as varied forms of learning or stimulation). In contrast, the high plasticity and directly controlled design and structure of AI software and hardware will render them well suited to altering themselves and hence to developing improved subsequent AI generations.

In addition to a jump in the degree of plasticity and its control, AIs will constitute a further step forward with regard to the speed at which beneficial information can be shared. In contrast to the exceedingly slow rate at which advantageous evolutionary adaptations were spread through the populations observed by Darwin (over several generations), the rapidly increasing rates of communication in current society result in successful “adaptations” (which we call science and technology) being distributed at ever-increasing speeds. This is, of course, the principal reason why information sharing is beneficial for humans – it allows us to better adapt to reality and harness the environment to our advantage. It seems reasonable to predict that ultimately the sharing of information in AI will be practically instantaneous.

It is difficult to speculate what a combination of such rapid communication and high plasticity combined with ever-increasing processing speeds will be like. The point at which self-improving AIs emerge has been termed a technological singularity (8).

Thus, in summary: evolution begets intelligence (via evolutionary neuronal selection mechanisms); human intelligence begets artificial intelligence (using, among others, evolutionary computation methods), which at increasing cycle speeds, leads to a technological singularity – a further big step up the evolutionary ladder.

Sadly, being considerably ahead of his time and living in an environment that castigated his lifestyle and drove him from his research, meant that Turing did not live to see the full extent of his work’s influence. While he did not survive to an age in which AIs became prevalent, he did fulfill his ambition by taking part in the defeat of argument from design in the scientific community, and witnessed Darwinian natural selection becoming widely accepted. The breadth of his vision, the insight he displayed, and his groundbreaking research clearly place Turing on an equal footing with the most celebrated scientists of the previous century.

…well, not quite. It appears that the price of mass gene sequencing is plummeting faster than the world’s stock markets, and a company called Complete Genomics has just announced it is offering full-genome sequencing for 5000$, putting this well within your average Joe’s buying power. As a comparison, remember that the first full sequencing in 2003 cost $2.3 billion!

scan0003

However, it’s important to note that the service will initially NOT be available to individuals, but will rather go to pharma companies and academics. This is interesting mainly because it is a sign of things to come – the coming age of personalized medicine will be based exactly on this presence of very low cost genome sequencing, allowing (or, perhaps, forcing) drug companies to include genome screening for their clinical trials patients in order to examine whether the side effects or benefits of their drugs are linked to specific genetic codes within the genome. One day this may become mandatory for marketing authorization…

While 5000$ a pop may still be a bit expensive for outsourcing and companies may yet cling to the machines they own, a company who focuses on sequencing will always ultimately prove cheaper in the long run, similar to any non-core outsourcing effort. Thus, Complete Genomics and the others of its ilk definitely have a future!

Bloomberg Story

In a major break with all things baby, a post about the universe, and pringles, and black holes. In a nutshell – physics. As Guy correctly called it: “Geek”.

So, a (long) recent New Scientist article suggest we may be living in a hologram. While that is a brain-warping idea, let’s first start with my favourite quote from this serious scientific article:

“…He showed that the physics inside a hypothetical universe with five dimensions and shaped like a Pringle is the same as the physics taking place on the four-dimensional boundary.”

The obvious questions here being: does god eat pringles? Would a dorito-shape universe not work better?

universe


In any case, apparently the fact that the GEO600 experiment (a gravitational wave detector in Germany)  had encountered weird background noise during it’s operation may mean that our daily lives are holographic projections from physical processes which take place on a remote 2D surface at the edge of the universe (next to the restaurant, of course). While this may sound either exciting, mind blowing or just plain weird (depending on your nerdiness quotient), apparently it’s quite a big deal in physics circles. Personally, it just sounds very sci-fi to me.

If you’re really interested, the physics beyond the fanciful title is based upon the fact that similar to the tiny quantum waves at black hole event horizons which encode the information inside black holes (thus solving the conundrum of how black holes slowly disappear without apparently losing information), the ripples at the edge of the universe encode the information inside the universe.  Thus, the 3-dimensional information concerning our universe and everything in may be encoded in ripples in the event horizon of the universe (“the boundary from beyond which light has not had time to reach us in the 13.7-billion-year lifespan of the universe”) .

How’s that for the ‘surprisingly different post of the month’ award then?


Source:  Our world may be a giant hologram

A recent TR article reports that researchers from UC San Diego and from Clarkson University in New York are aiming to develop a chip which will continuously monitor soldiers’ physiological chemistry (initially glucose, oxygen, lactase, and norepinephrine) via enzymatic sensors. At signs of substantial changes to normal levels of the markers, the chip, carried externally but connected to the soldiers’ systems via electrodes and presumably tubing,  will be able to release the appropriate chemicals to give initial treatment to the injured. This rapid diagnosis and treatment is crucial in the battlefield, where the majority of deaths occur within half an hour of injury.

Smart sensor

While this development is certainly on the books and will sooner or later be realized, as both critical need and technology are there (or feasible with current and near future levels of technology), the reported “4 years to completion” seem overly optimistic, perhaps they are talking about a very rudimentary prototype.

Besides the complexity of getting the enzymatic reactions and proposed logic gates right, transferring biotechnology which works in solution in the lab to external conditions can take years. Furthermore, the ability to incorporate these into a chip which is rugged enough and retains its operation in battlefield conditions will take substantial time and effort. This without mentioning the rigorous quality testing these chips will need to undergo to ensure no malfunctions, which may be life-threatening.

The current design speaks of an external chip which monitors the soldier’s condition via electrodes implanted subcutaneously or at other locations. Such connections will have to overcome numerous obstacles, both engineering- and biology-related. Further system generations involving implantable chips (for which immunological scarring and other difficulties will have to be overcome) are even further away and will be the target of such development.

While these advanced models may take a long time to develop, this project may end up pushing through technology which can prove extremely useful in “civilian” medicine as well, similar to many DARPA projects. Imagine being able to implant medical chips into patients, with these monitoring all vital signs and markers continuously and releasing therapeutic compounds at the precise time and quantity required. These chips will also be able to communicate wirelessly with the physician, and allow perfect monitoring and immediate treatment of patients’ condition.

Source:

Battlefield Medic on a Chip

Time magazine has released its top inventions for the year, and topping the list is the much-heralded 23andMe retail DNA sequencing kit. Beyond the hype factor, which is bolstered by Sergey Brin’s wife being the co-founder, the question is what can people get from getting such a test done at this stage.

Don’t get me wrong – sequencing technology and its move into the retail domain have been a long time coming and will take part in changing the medical landscape in the coming decades. However, this is the problem these test currently face – it will take that long to change from a cool, futuristic gimmick which gives people taking it in-depth knowledge about their genome and the diseases they may be more likely to have over their lifetime to a test result which can directly lead to targeted preventive therapy and compensating for any potential problems stemming from specific underpar genes.

The 23andMe test

The 23andMe test

No doubt, the big cheeses who have invested in this venture (google, among others) realize very well that it is a long-term effort that will take many years to fulfill its promise. Moreover – this fulfillment will not come from the company but rather from medical research moving forward and ushering in  the much vaunted era of personalized medicine.

Once again, a few years off as yet.

However, this does not spoil the chance for all the luddites to cry foul and cite all sorts of reasons why this development should be restricted. As expected, many will try to piggyback on an emerging, potentially paradigm-changing development and make some noise, each for their own agenda.

The potential of personalized medicine is so huge – it will become as commonplace as current medicine is, for the simple reason that targeting medicinces to patients by their unique genetics will make therapies more safe, effective and will thus increase both life quality and length. And that is what medicine is all about, and what patients will want.

Source:

TIME’s Best Inventions of 2008

http://www.time.com/time/specials/packages/article/0,28804,1852747_1854493_1854113,00.html